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Zhu Y, et al. | Read full study
This meta-analysis (11 randomized controlled trials with 1410 patients) suggests that vapocoolant spray significantly decreased pain during intravenous cannulation when compared with placebo spray or no treatment in both adults and children.
Mace, SE et al. Department of Emergency Medicine, Cleveland Clinic | Read full study
The median pain of venipuncture was 3 in the placebo group and 1 in the vapocoolant group, P < .001.